Reelin Promotes Neuronal Orientation and Dendritogenesis during Preplate Splitting
نویسندگان
چکیده
منابع مشابه
Reelin promotes neuronal orientation and dendritogenesis during preplate splitting.
The secreted ligand Reelin is thought to regulate the translocation and positioning of prospective layer 6 (L6) neurons into the preplate, a plexus of neurons overlying the ventricular zone. We examined wild type and Reelin-deficient cortices and found that L6 neurons were equivalently positioned beneath the pia during the period of preplate splitting and initial cortical plate (CP) formation. ...
متن کاملRescue of Ataxia and Preplate Splitting by Ectopic Expression of Reelin in reeler Mice
The gene mutated in reeler (reelin) encodes a protein secreted by neurons in the developing brain that controls laminar positioning of migrating cells in the CNS by an unknown mechanism. To investigate Reelin function, we used the nestin promoter to express Reelin ectopically in the ventricular zone and other brain regions in transgenic mice. In the presence of the endogenous protein, ectopic R...
متن کاملReduction of Crk and CrkL expression blocks reelin-induced dendritogenesis.
The reelin signaling pathway regulates nervous system function after birth, in addition to its role in regulating neuronal positioning during embryogenesis. The receptor-dependent, reelin-induced tyrosine phosphorylation of the Dab1 docking protein is an established prerequisite for biological responses to this ligand. Here we show that the inactivation of a conditional Dab1 allele reduces proc...
متن کاملThe dynamic recruitment of TRBP to neuronal membranes mediates dendritogenesis during development
MicroRNAs are important regulators of local protein synthesis during neuronal development. We investigated the dynamic regulation of microRNA production and found that the majority of the microRNA-generating complex, consisting of Dicer, TRBP, and PACT, specifically associates with intracellular membranes in developing neurons. Stimulation with brain-derived neurotrophic factor (BDNF), which pr...
متن کاملComment on “Reelin Promotes Peripheral Synapse Elimination
Individual synaptic sites on rodent skeletal muscle fibers are innervated by two or more axons at birth. All inputs but one are then eliminated during the first two postnatal weeks, leaving each muscle fiber singly innervated (1). Quattrocchi et al. (2) reported that polyneuronal innervation of neuromuscular synapses persists well beyond this period in reeler mice (mutant mice lacking Reelin, a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cerebral Cortex
سال: 2010
ISSN: 1460-2199,1047-3211
DOI: 10.1093/cercor/bhp303